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CIALIS

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MECHANISM

  • Cialis increases blood flow to the penis which allows a man to achieve an erection.
  • When a man is sexually stimulated, nitric oxide is released into the penis. Nitric oxide enables the production of cGMP, which controls the dilation and contraction of the blood vessels that carry blood to and from the penis.
  • Another substance, PDE5, destroys cGMP. When this occurs, the blood vessels return to their normal size, and the erection ends. Tadalafil stops PDE5 from destroying cGMP. This causes the erection to last for longer.
  • The muscles of the arteries in the walls of the lungs also contain PDE5, which is why the same drug can also help with pulmonary hypertension treatment.

WARNING

  • The FDA has warned about sudden hearing loss experienced by a lot of people due to these drugs.
  • The FDA, in 2016 announced that they were taking precautionary measures following indications that using cialis might increase the risk of melanoma skin cancer.